USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: ODPA_HUMAN USC-OGP 2-DE database:  ODPA_HUMAN ODPA_HUMAN General information about the entry View entry in simple text format Entry name ODPA_HUMAN Primary accession number P08559 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; EC=1.2.4.1; AltName: Full=PDHE1-A type I; Flags: Precursor;. Gene name Name=PDHA1 Synonyms=PHE1A Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1185: pI=6.07; Mw=43048 Cross-references UniProtKB/Swiss-Prot P08559; ODPA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ODPA_HUMAN Primary accession number P08559 Secondary accession number(s) A5YVE9 B2R5P7 B7Z3T7 B7Z3X5 Q53H41 Q5JPT8 Q9NP12 Q9UBJ8 Q9UBU0 Q9UNG4 Q9UNG5 Sequence was last modified on  May 1, 1992 (version 3) Annotations were last modified on  March 15, 2017 (version 209) Name and origin of the protein Description RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; EC=1.2.4.1; AltName: Full=PDHE1-A type I; Flags: Precursor; Gene name Name=PDHA1 Synonyms=PHE1A Encoded on Name=PDHA1; Synonyms=PHE1A Keywords 3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Glucose metabolism; Leigh syndrome; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide; Tricarboxylic acid cycle. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D90084; BAA14121.1; -; Genomic_DNA EMBL M24848; AAA36533.1; -; mRNA EMBL X52709; CAA36933.1; -; mRNA EMBL X52710; CAA36934.1; -; mRNA EMBL M27257; AAA60051.1; -; Genomic_DNA EMBL M29155; AAA60051.1; JOINED; Genomic_DNA EMBL M29156; AAA60051.1; JOINED; Genomic_DNA EMBL M29157; AAA60051.1; JOINED; Genomic_DNA EMBL M29158; AAA60051.1; JOINED; Genomic_DNA EMBL M29159; AAA60051.1; JOINED; Genomic_DNA EMBL M29160; AAA60051.1; JOINED; Genomic_DNA EMBL M29161; AAA60051.1; JOINED; Genomic_DNA EMBL M29162; AAA60051.1; JOINED; Genomic_DNA EMBL M29163; AAA60051.1; JOINED; Genomic_DNA EMBL M29164; AAA60051.1; JOINED; Genomic_DNA EMBL L13318; AAA60227.1; -; mRNA EMBL J03503; AAA60055.1; ALT_INIT; mRNA EMBL J03575; AAA60050.1; -; mRNA EMBL L48690; AAB59581.1; ALT_FRAME; mRNA EMBL EF590117; ABQ59099.1; -; mRNA EMBL AK293250; BAH11476.1; -; mRNA EMBL AK296457; BAH12361.1; -; mRNA EMBL AK312263; BAG35194.1; -; mRNA EMBL AK296341; BAH12323.1; -; mRNA EMBL AK222740; BAD96460.1; -; mRNA EMBL AL732326; CAI41291.1; -; Genomic_DNA EMBL CH471074; EAW98960.1; -; Genomic_DNA EMBL BC002406; AAH02406.1; -; mRNA EMBL AF125053; AAD23841.1; -; Genomic_DNA EMBL AF125054; AAD23842.1; -; Genomic_DNA EMBL AF125055; AAD23843.1; -; Genomic_DNA EMBL AF125056; AAD23844.1; -; Genomic_DNA EMBL AF125057; AAD23845.1; -; Genomic_DNA EMBL AF125058; AAD23846.1; -; Genomic_DNA EMBL AF125059; AAD23847.1; -; Genomic_DNA EMBL AF125060; AAD23848.1; -; Genomic_DNA EMBL AF125061; AAD23849.1; -; Genomic_DNA EMBL AF125062; AAD23850.1; -; Genomic_DNA EMBL AF125063; AAD23851.1; -; Genomic_DNA EMBL AF125064; AAD23852.1; -; Genomic_DNA EMBL AF125065; AAD23853.1; -; Genomic_DNA EMBL AF125066; AAD23854.1; -; Genomic_DNA EMBL AF125067; AAD23855.1; -; Genomic_DNA EMBL AF125068; AAD23856.1; -; Genomic_DNA EMBL AF125069; AAD23857.1; -; Genomic_DNA EMBL AF125070; AAD23858.1; -; Genomic_DNA EMBL AF125071; AAD23859.1; -; Genomic_DNA EMBL AF125072; AAD23860.1; -; Genomic_DNA EMBL AF125073; AAD23861.1; -; Genomic_DNA EMBL AF125074; AAD23862.1; -; Genomic_DNA EMBL AF125075; AAD23863.1; -; Genomic_DNA EMBL AF125076; AAD23864.1; -; Genomic_DNA EMBL AF125078; AAD23866.1; -; Genomic_DNA EMBL AF125079; AAD23867.1; -; Genomic_DNA EMBL AF125080; AAD23868.1; -; Genomic_DNA EMBL AF125081; AAD23869.1; -; Genomic_DNA EMBL AF125082; AAD23870.1; -; Genomic_DNA EMBL AF125083; AAD23871.1; -; Genomic_DNA EMBL AF125084; AAD23872.1; -; Genomic_DNA EMBL AF125085; AAD23873.1; -; Genomic_DNA EMBL AF125086; AAD23874.1; -; Genomic_DNA EMBL AF125087; AAD23875.1; -; Genomic_DNA EMBL AF125088; AAD23876.1; -; Genomic_DNA CCDS CCDS14192.1; -. [P08559-1]; . CCDS CCDS55380.1; -. [P08559-4]; . CCDS CCDS55381.1; -. [P08559-2]; . CCDS CCDS55382.1; -. [P08559-3]; . PIR JQ0770; DEHUPA; . RefSeq NP_000275.1; NM_000284.3. [P08559-1]; . RefSeq NP_001166925.1; NM_001173454.1. [P08559-4]; . RefSeq NP_001166926.1; NM_001173455.1. [P08559-2]; . RefSeq NP_001166927.1; NM_001173456.1. [P08559-3]; . UniGene Hs.530331; -; . PDB 1NI4; X-ray; 1.95 A; A/C=30-390 PDB 2OZL; X-ray; 1.90 A; A/C=30-390 PDB 3EXE; X-ray; 1.98 A; A/C/E/G=30-390 PDB 3EXF; X-ray; 3.00 A; A/C/E/G=30-390 PDB 3EXG; X-ray; 3.01 A; 1/3/5/A/C/E/G/I/K/M/O/Q/S/U/W/Y=30-390 PDB 3EXH; X-ray; 2.44 A; A/C/E/G=30-390 PDB 3EXI; X-ray; 2.20 A; A=30-390 PDBsum 1NI4; -; . PDBsum 2OZL; -; . PDBsum 3EXE; -; . PDBsum 3EXF; -; . PDBsum 3EXG; -; . PDBsum 3EXH; -; . PDBsum 3EXI; -; . ProteinModelPortal P08559; -; . SMR P08559; -; . BioGrid 111186; 52; . DIP DIP-37652N; -; . IntAct P08559; 19; . MINT MINT-3006251; -; . DrugBank DB00157; NADH; . iPTMnet P08559; -; . PhosphoSitePlus P08559; -; . SwissPalm P08559; -; . BioMuta PDHA1; -; . DMDM 129063; -; . REPRODUCTION-2DPAGE IPI00306301; -; . UCD-2DPAGE P08559; -; . EPD P08559; -; . MaxQB P08559; -; . PeptideAtlas P08559; -; . PRIDE P08559; -; . TopDownProteomics P08559-3; -. [P08559-3]; . TopDownProteomics P08559-4; -. [P08559-4]; . DNASU 5160; -; . Ensembl ENST00000379806; ENSP00000369134; ENSG00000131828. [P08559-4]; . Ensembl ENST00000422285; ENSP00000394382; ENSG00000131828. [P08559-1]; . Ensembl ENST00000540249; ENSP00000440761; ENSG00000131828. [P08559-3]; . Ensembl ENST00000545074; ENSP00000438550; ENSG00000131828. [P08559-2]; . GeneID 5160; -; . KEGG hsa:5160; -; . UCSC uc004czg.5; human. [P08559-1]; . CTD 5160; -; . DisGeNET 5160; -; . GeneCards PDHA1; -; . HGNC HGNC:8806; PDHA1; . HPA HPA047487; -; . HPA HPA047864; -; . HPA HPA063053; -; . MalaCards PDHA1; -; . MIM 300502; gene; . MIM 312170; phenotype; . neXtProt NX_P08559; -; . OpenTargets ENSG00000131828; -; . Orphanet 70474; Leigh syndrome with cardiomyopathy; . Orphanet 79243; Pyruvate dehydrogenase E1-alpha deficiency; . PharmGKB PA33150; -; . GeneTree ENSGT00530000063174; -; . HOGENOM HOG000281336; -; . HOVERGEN HBG001863; -; . InParanoid P08559; -; . KO K00161; -; . OMA WMYQKML; -; . OrthoDB EOG091G0966; -; . PhylomeDB P08559; -; . TreeFam TF300742; -; . BioCyc MetaCyc:HS05573-MONOMER; -; . BRENDA 1.2.4.1; 2681; . Reactome R-HSA-204174; Regulation of pyruvate dehydrogenase (PDH) complex; . Reactome R-HSA-389661; Glyoxylate metabolism and glycine degradation; . Reactome R-HSA-5362517; Signaling by Retinoic Acid; . Reactome R-HSA-70268; Pyruvate metabolism; . SABIO-RK P08559; -; . SIGNOR P08559; -; . ChiTaRS PDHA1; human; . EvolutionaryTrace P08559; -; . GeneWiki Pyruvate_dehydrogenase_(lipoamide)_alpha_1; -; . GenomeRNAi 5160; -; . PRO PR:P08559; -; . Proteomes UP000005640; Chromosome X; . Bgee ENSG00000131828; -; . CleanEx HS_PDHA1; -; . ExpressionAtlas P08559; baseline and differential; . Genevisible P08559; HS; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005730; C:nucleolus; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0045254; C:pyruvate dehydrogenase complex; IDA:UniProtKB; . GO GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC; . GO GO:0034604; F:pyruvate dehydrogenase (NAD+) activity; IEA:Ensembl; . GO GO:0004738; F:pyruvate dehydrogenase activity; IDA:UniProtKB; . GO GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:UniProtKB; . GO GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW; . GO GO:0046487; P:glyoxylate metabolic process; TAS:Reactome; . GO GO:0061732; P:mitochondrial acetyl-CoA biosynthetic process from pyruvate; IEA:Ensembl; . GO GO:0006090; P:pyruvate metabolic process; TAS:Reactome; . GO GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome; . GO GO:0006099; P:tricarboxylic acid cycle; IDA:UniProtKB; . Gene3D 3.40.50.970; -; 1; . InterPro IPR001017; DH_E1; . InterPro IPR017597; Pyrv_DH_E1_asu_subgrp-y; . InterPro IPR029061; THDP-binding; . Pfam PF00676; E1_dh; 1; . SUPFAM SSF52518; SSF52518; 1; . TIGRFAMs TIGR03182; PDH_E1_alph_y; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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